منابع مشابه
Treatment of murine Candida krusei or Candida glabrata infection with L-743,872.
L-743,872 is a broad-spectrum pneumocandin antifungal drug developed by Merck Research Co., and in the present work it was evaluated in vivo in murine models of Candida krusei and Candida glabrata infection. Mice were infected intravenously with two isolates of C. krusei and treated with fluconazole or L-743,872. Fluconazole was beneficial only in immune-competent mice infected with isolate 94-...
متن کاملEfficacy of triazoles in a murine disseminated infection by Candida krusei.
We evaluated the efficacies of posaconazole and voriconazole in comparison with that of amphotericin B in a systemic murine infection by Candida krusei. Posaconazole at 50 mg/kg/day and voriconazole at 40 and 60 mg/kg/day prolonged survival and reduced the fungal tissue burden in the kidneys of mice similarly to amphotericin B at 1.5 mg/kg/day and liposomal amphotericin B at 10 mg/kg/day. None ...
متن کاملA cluster of Candida krusei infections in a haematological unit
BACKGROUND Candida krusei infections are associated with high mortality. In order to explore ways to prevent these infections, we investigated potential routes for nosocomial spread and possible clonality of C. krusei in a haematological unit which had experienced an unusually high incidence of cases. METHODS We searched for C. krusei contamination of the hospital environment and determined t...
متن کاملRenal allograft pyelonephritis and fungemia due to Candida krusei
A 61-year-old female was admitted for fever and acute renal failure 6 weeks after receiving a kidney transplant. Her past medical history was notable for CKD stage 5 due to chronic idiopathic tubulointerstitial nephritis. This was diagnosed in 1998 when she presented with an elevated creatinine, sterile pyuria and proteinuria, and underwent native kidney biopsy confirming the diagnosis. She was...
متن کاملUpregulation of the ERG11 gene in Candida krusei by azoles
BACKGROUND AND THE PURPOSE OF THE STUDY Candida species are the agents of local and systemic opportunistic infections and have become a major cause of morbidity and mortality in the last few decades. Azole resistance in Candida krusei (C. krusei) species appears to be the result of gene alterations in relation to the ergosterol biosynthesis pathway, as well as efflux pumps. The main objective o...
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ژورنال
عنوان ژورنال: Annals of Pediatric Cardiology
سال: 2010
ISSN: 0974-2069
DOI: 10.4103/0974-2069.64355